• br Conflicts of interest br Acknowledgment br Introduction T

  2022-04-09

  

  Conflicts of interest Acknowledgment Introduction The ganciclovir receptor growth factor receptors (FGFRs) are a family members of receptor tyrosine kinase (RTK) that represent attractive therapeutic targets for anti-cancer therapy gaining more and more attention in recent years [1], [2].

• br Ferroptosis modulators With the

  2022-04-09

  

  Ferroptosis modulators With the recognition that the small molecule erastin targets system xc- and thereby specifically triggers this form of death and that ferrostatin-1 prevents erastin-induced ferroptosis [2], it has become evident that ferroptosis is a druggable pathway with a number of tract

• br Introduction The term autophagy

  2022-04-09

  

  Introduction The term “autophagy” was coined by Christian de Duve in 1963 to describe the process of removing and degrading intracellular components such as unused proteins and damaged organelles through lysosomes [1,2]. Autophagy has been divided into three main types, namely, macroautophagy, mi

• The progression of HIV varies from patient to patient

  2022-04-09

  

  The progression of HIV varies from patient to patient, with some who progress slowly and others who progress much faster. However, CD4+ and CD8+ cell counts are intimately linked in those that are able to suppress the HIV infection (Walker et al., 1986; Saez-Aninon et al., 2007). Depletion of these

• At baseline Hdc KO mice have alterations in

  2022-04-09

  

  At baseline, Hdc-KO mice have alterations in the examined signaling cascades that resemble those seen in WT mice after RAMH challenge. Specifically, Isorhamnetin of MSK1 at T581 and of rpS6 ad S235/236 are elevated in dMSNs to a similar extent after saline in KO mice and after RAMH challenge in WT

• br Materials and methods br Results br Discussion

  2022-04-09

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either HOSu H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the receptor´s respons

• It is noticeable that CO as well

  2022-04-09

  

  It is noticeable that CO as well as H. pylori suppresses apoptosis while it induces autophagy in AGS cells. The differential effects of CO on the activation of transcription factors responsible for regulating expression of apoptosis- and autophagy-related genes merit further investigation. In concl

• Mathematical models play an important role

  2022-04-08

  

  Mathematical models play an important role in understanding and predicting the dynamic process of HBV infection. In the 1990s, Nowak et al. proposed a basic model to analyze the effect of antiviral treatment on reducing viral loads (Nowak et al., 1996). Since then, many different mathematical models

• UV vis spectra of hsGC proteins were recorded

  2022-04-08

  

  UV–vis spectra of hsGC proteins were recorded with an HP8453 UV–vis spectrophotometer at 20°C. The corresponding ferrous, CO-bound and NO-bound species were prepared with the similar published procedure [7], [15]. The heme transfer reactions were performed by a UV–vis spectrometer with kinetic mode

• In the present study we observed a

  2022-04-08

  

  In the present study, we observed a decrease in body weight gain in Tg rats. It is uncertain whether this effect is due to Denr, Gpr81, or Gpr109a. In this regard, Gpr81 mice have been reported to have reduced body weight gain [28]. Moreover, a small clinical study has reported that obese patients t

• br Materials and methods br Results br Discussion Previously

  2022-04-08

  

  Materials and methods Results Discussion Previously, it is well known that methionine and choline deficient (MCDD) or choline-deficient, L-amino acid-defined (CDAA) models are widely accepted in NASH research. MCDD or CDAA dietary model has been mimic human NASH in rodents by sequentially p

• The pharmacokinetics of was obtained in mouse rat

  2022-04-08

  

  The pharmacokinetics of was obtained in mouse, rat and dog to determine if it had a suitable profile to investigate the effects of the GPR120 mechanism (). had an adequate half-life, low clearance in all 3 species, and high blood levels and bioavailability. The low volume of distribution (V) indi

• To determine the functional consequences of

  2022-04-08

  

  To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD

• Cichlasoma dimerus as most teleost

  2022-04-08

  

  Cichlasoma dimerus, as most teleost fish species, present neurons expressing GnRH3 (Pandolfi et al., 2005). As in most Dihydrodaidzein receptor species, the neurons expressing GnRH3 are mainly located in the NOR, although few neurons were detected in the olfactory bulb, ventral telencephalon and th

• br Expression of GlyT in the spinal cord

  2022-04-08

  

  Expression of GlyT in the spinal cord in response to neuropathic pain Twelve days after sham injury or CCI, GlyT1 and GlyT2 mRNA expression in rat spinal cord was analyzed using qPCR. Here, no significant changes in expression of the transporters in our CCI model of neuropathic pain compared with

15772 records 447/1052 page Previous Next First page 上5页 446447448449450 下5页 Last page