• With regard to safety issues prolonged differentiation Brede

  2018-11-06

  

  With regard to safety issues, prolonged differentiation (Brederlau et al., 2006; Doi et al., 2012) and purification of neurally committed cells (Fukuda et al., 2006; Pruszak et al., 2009; Sundberg et al., 2013) have been attempted to reduce the risk of tumor formation. Recently, a dual SMAD inhibiti

• The following are the supplementary data related to

  2018-11-06

  

  The following are the supplementary data related to this article. Introduction Materials and methods Results Discussion Within the human body, three mechanisms of blood vessel formation can be distinguished, namely vasculogenesis, arteriogenesis and angiogenesis. In particular angiogene

• Introduction Since the discovery that somatic cells could be

  2018-11-06

  

  Introduction Since the discovery that somatic cells could be reprogrammed to induced pluripotent stem cells (iPSCs) (Takahashi and Yamanaka, 2006), many different pathways have been created based on Waddington\'s Bioactive Compound Library of the “epigenetic landscape”, the model used to illustrat

• Discussion We previously reported that the conventional gene

  2018-11-06

  

  Discussion We previously reported that the conventional genetic depletion of Pelo in mouse results in an embryonic lethality at early post-implantation stages (Adham et al., 2003). Here, we report that Pelo-null ESCs are continuously propagated and retained their capacity to form undifferentiated c

• To assess the applicability of

  2018-11-06

  

  To assess the applicability of our method, we selected three binary-fate stem cell differentiation systems for which high-quality single-cell gene expression data are available. These examples include the differentiation of inner cell mass (ICM) into either primitive endoderm (PE) or epiblast (EPI)

• br Resource table Resource details

  2018-11-06

  

  Resource table Resource details We reprogrammed fibroblasts obtained from a patient with Familial Mediterranean Fever (FMF), an autosomal recessively inherited autoinflammatory disease caused by mutations in the MEFV gene (The International FMF Consortium, 1997; French FMF Consortium, 1997). Pat

• Overall ten genes five of

  2018-11-06

  

  Overall, ten genes, five of which are coding genes (FMOD, SULF1, COL12A1, STMN2 and MAEL), and five long-non-coding RNA (lncRNA) genes, were differentially expressed in hUC cells. lncRNAs are non-protein coding transcripts longer than 200 nucleotides. They have been implicated in the regulation of g

• HSCs isolated by the set of markers which are

  2018-11-06

  

  HSCs isolated by the set of markers which are Lin−/Sca-1+/C-kit+ (LSK) have been also reported to be heterogeneous (Osawa et al., 1996). Moreover, Sca-1 expression differs between mouse strains and therefore is not very effective to enrich HSCs (Spangrude and Brooks, 1993). Likewise, the SLAM family

• In the present study we demonstrated the potential

  2018-11-05

  

  In the present study, we demonstrated the potential of hiPSC-CMs to reflect an adverse drug response in healthy individuals. However, as mentioned above, studies in larger cohorts of individuals and using various types of drugs will be required to translate this chk1 potential into practical applic

• br Results br Discussion Although hiPSCs have been directed

  2018-11-05

  

  Results Discussion Although hiPSCs have been directed to differentiate into various organoids/tissues and in vitro differentiation from bovine iPSCs toward a partial mammary phenotype has been reported (Cravero et al., 2015), generation of mammary organoids/cells from hiPSCs has not been estab

• br Results br Discussion PSC offer

  2018-11-05

  

  Results Discussion PSC offer great opportunities for human health, allowing the derivation of patient-specific tissues and providing disease models for drug screening. Thus, investigation of factors and mechanisms that regulate pluripotency constitutes a rapidly growing area of cutting-edge re

• Acceleration of neutrons in the uniform magnetic field by me

  2018-11-05

  

  Acceleration of neutrons in the uniform magnetic field by means of a radio-frequency flipper is well known and successfully used in physical experiments (see, e.g., Ref. [7]). The phenomenon of neutron acceleration in a strong alternating magnetic field (of amplitude ∼0.4T) was observed in Ref. [8].

• br Deposition of MgSe thin films MgSe thin solid

  2018-11-05

  

  Deposition of MgSe thin films MgSe thin solid films were prepared using the versatile spray pyrolysis technique, which is simple and economic as compared to the MBE and MOCVD methods. The properties of the film can be controlled by adjusting the preparative parameters such as substrate temperatur

• where and are the radial and the axial sizes

  2018-11-05

  

  where and are the radial and the axial sizes of the eddies, is the characteristic flow velocity. For the experiment described in this paper, the value of the axial velocity, averaged over the measurement time, for the point C on the container axis with the coordinates r = 0mm, z = 60mm (see Fig.

• br Limitations There are several limitations to our analysis

  2018-11-05

  

  Limitations There are several limitations to our analysis. First, despite the comparative nature of the ESS, it neuraminidase inhibitor is plausible that the definition of temporary employment and the criteria according to which individuals rate their own health may differ across countries (Jylh

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