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TSA a HDAC inhibitor has a differential
2018-10-20
TSA, a HDAC inhibitor, has a differential affinity to bind various HDAC complexes (Bantscheff et al., 2011). In the present study, ChIP analysis revealed that HDAC2 and HDAC3 are bound with higher affinity to the Cyclin B1 promoter in BMSCs and the Cyclin D2 promoter in HSPCs, which inhibits the exp
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In this study we evaluated if different and
2018-10-20
In this study, we evaluated if different and distant anatomic regions of fat depots, albeit limited to the thoracic cavity, might reflect a heterogeneous array of biological, functional and ultrastructural features of ASCs. Our results support previous findings on putative differences between ASC po
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The karyotype of the BIOT EHMT iPSC line
2018-10-20
The karyotype of the BIOT-0708-EHMT1 iPSC line was determined with Giemsa-banding, proving normal diploid 46, XX karyotype, without any detectable abnormalities (Fig. 1B). In parallel, the pathogenic NM_024757.4(EHMT1):c.3413G>A mutation was confirmed by Sanger sequencing in the newly established iP
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leukotriene receptor antagonist Recent studies have proposed
2018-10-20
Recent studies have proposed the involvement of CSCs/progenitor leukotriene receptor antagonist in cancer initiation, progression, metastasis and therapy failure (Cariati and Purushotham, 2008; Gonzalez-Sarmiento and Perez-Losada, 2008; Lawson et al., 2009; Liu et al., 2005; Lynch et al., 2006; Pont
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br Introduction Capable of almost unlimited proliferation an
2018-10-20
Introduction Capable of almost unlimited proliferation and efficient differentiation into cardiomyocytes (Yang et al., 2008; Lian et al., 2012; Elliott et al., 2011), hPSCs open a new route for the research of human sodium channel blockers development and heart diseases, drug development, and mo
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We used immunohistochemistry to measure the expression
2018-10-20
We used immunohistochemistry to measure the expression of RUNX2, SP7, and GFP in the induced 2.3 kb Col1a1-GFP mESCs. RUNX2, SP7, and the 2.3 kb Col1a1-GFP were highly expressed in the induced terbinafine hydrochloride on day 19. RUNX2 and SP7 were colocalized in nuclei, and 2.3 kb Col1a1-GFP was l
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Despite PTC characterization as a tumor suppressor Goodrich
2018-10-20
Despite PTC characterization as a tumor suppressor (Goodrich et al., 1997), we observed that its deletion in astrocyte-like NSCs increases the stemness of these Homoharringtonine without promoting tumor formation. Our data are consistent with the results observed upon the noninducible deletion of P
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br Acknowledgments br Introduction In
2018-10-20
Acknowledgments Introduction In the adult hematopoietic system, short-lived mature dna stain are constantly lost and need to be replaced in order to maintain blood homeostasis (Murphy et al., 2005; Weissman and Shizuru, 2008). This essential task is fulfilled by hematopoietic stem cells (HSCs
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Treatment options for xerostomia include administration
2018-10-20
Treatment options for xerostomia include administration of saliva substitutes or stimulants (Fox, 2004). Saliva substitutes might improve some, but not all, problems associated with SG dysfunction, whereas stimulants are only useful for people with some remaining SG function. Alternative approaches
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The dynamic clonal behavior and conversion of leukemic pheno
2018-10-20
The dynamic clonal behavior and conversion of leukemic lgk974 that we observed in our mouse model show resemblance with patients presenting with leukemic relapse after treatment. First, if remissions in relapsed patients are treated similarly as the original leukemia, the response is often differen
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A variety of suitable murine xenograft models are currently
2018-10-20
A variety of suitable murine xenograft models are currently used in hematopoietic research, yet these animals require conditioning prior to experimentation. Given the increasingly restricted access to radiation sources, NBSGW mice are broadly enabling, allowing laboratories without access to radiati
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Our observation that EGF signaling is
2018-10-20
Our observation that EGF signaling is required for the generation of the equivalent of second-transition progenitors in hPSC differentiation cultures is in line with findings from targeting studies in the mouse that showed that EgfR/ErbB1−/− and ErbB3−/− deficient animals display impaired branching
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br Heteroplasmy mitochondrial segregation and disease In
2018-10-20
Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome
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To determine whether overexpression of
2018-10-20
To determine whether overexpression of Sca-1 in progenitor cells residing in the bulge and upper isthmus could function as an initiating event, Rosa:Cre mice and control littermates were treated with TPA only. This treatment resulted in very few papillomas that quickly regressed and there was no sig
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In conclusion the MC approach
2018-10-20
In conclusion, the MC approach described in this study provides a platform to generate a population of human PAX7+ myogenic progenitors from PS vorinostat that can be terminally differentiated into MHC+ myocytes in vitro that is equivalent to iPAX7 cells. However, further development of the method
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