• br Introduction During early embryogenesis ectoderm differen

  2018-11-08

  

  Introduction During early embryogenesis, ectoderm differentiates into surface ectoderm, neural crest, and neural tube. From the surface ectoderm, oral ectoderm and skin develop [1]. In turn, the oral ectoderm differentiates into the adenohypophysis [2,3], dental epithelia [1], salivary glands [1]

• br Material methods br Results br

  2018-11-08

  

  Material & methods Results Discussion Acknowledgements We thank Melissa Carballosa-Gautam in the Miami Project to Cure Paralysis Imaging Core. This design, experimentation, data analysis and manuscript writing was supported by the Miami Project to Cure Paralysis; NIH/NINDS (DJL: NS049545

• br Materials and methods br Author disclosure statement br

  2018-11-08

  

  Materials and methods Author disclosure statement Acknowledgments This study was supported by fund from National Medical Research Council (NMRC) of China to SZ (fund number: 30400447) and HW (fund number: 30500548). Resource table. Resource details To engineer a biallelic mutation in t

• br Experimental Procedures br Acknowledgments br Introductio

  2018-11-08

  

  Experimental Procedures Acknowledgments Introduction Hepatitis C virus (HCV) infects an estimated 2%–3% of the world population and is a major cause of liver disease and cancer. It is estimated that more than 350,000 people die of the HCV-related liver disease each year (Te and Jensen, 2010

• We initially tested this system s capacity to

  2018-11-08

  

  We initially tested this system’s capacity to induce epigenetic reprogramming toward the SkM lineage in C3H10T1/2 PR171 previously shown to readily undergo this transformation (Davis et al., 1987). We designed three separate gRNAs (1–3) targeted to different positions proximal to the Myod1 transcri

• With regard to prepubertal testicular tissue an important co

  2018-11-08

  

  With regard to prepubertal testicular tissue, an important concern for IVM is proper establishment of the blood testis barrier (BTB) during the peripubertal period. Several studies have demonstrated a correlation between dysfunction of the BTB and impaired spermatogenesis (Cavicchia et al., 1996), a

• In summary we demonstrate that GRM

  2018-11-08

  

  In summary, we demonstrate that GRM7 functions as a modulator of neurogenesis. We identify CREB, YAP, and CYCLIND1 as the downstream targets of GRM7. The phosphorylation of CREB at Ser133 and the expression of YAP and CyclinD1 are modulated by GRM7, thereby regulating neurogenesis. Future behaviora

• br Conclusion The number of colonies at

  2018-11-08

  

  Conclusion The number of colonies at the first isolation step could only represent a more or less rich ECFC content of the donor but we demonstrated that the initial clonogenicity was also related to distinctive intrinsic stemness, proliferative and functional features. Moreover, our results enab

• br Main Text br Acknowledgments br Main Text br Acknowledgme

  2018-11-08

  

  Main Text Acknowledgments Main Text Acknowledgments Introduction Pluripotent stem Atractyloside Dipotassium Salt (PSCs) are defined by their ability for self-renewal and the capacity to differentiate into cells of the three embryonic germ layers: ectoderm, endoderm, and mesoderm (Tho

• Expression profiles from tumor tissue and derived cell lines

  2018-11-08

  

  Expression profiles from tumor tissue and derived cell lines are extremely different, thus the current transcriptomic signature for GBM subtyping may not apply in vitro. Using our precursor state signature, we were able to identify an association with the proneural and mesenchymal subtypes. Interest

• br Results br Discussion FLT and

  2018-11-08

  

  Results Discussion FLT3 and KIT are key RTKs controlling HSPCs. Ubiquitination and dephosphorylation are two important mechanisms to negatively regulate RTK signaling (Dikic and Giordano, 2003; Sastry and Elferink, 2011). These data are in agreement with observations made in CBL and Itch knoc

• br Results br Discussion Two different

  2018-11-08

  

  Results Discussion Two different lineages of BAs have been known. Classical BAs are derived from Myf-5 expressing common progenitors for myoblasts and BAs (Seale et al., 2008). The myoblastic precursors originate from the mesenchymal stem diindolylmethane (MSCs). PRDM16 is crucially involved

• We sought to determine whether T cell

  2018-11-08

  

  We sought to determine whether T cell-derived iPSCs (TiPSCs) could be used to analyze neurological diseases. Several issues regarding the utilization of TiPSCs in neurological studies remain unresolved. First, previous studies indicated that each iPSC clone retains an epigenetic memory relating to t

• br Results br Discussion Yamanaka

  2018-11-08

  

  Results Discussion Yamanaka factors induce somatic cell reprogramming to iPSCs by promoting spatiotemporal expression of PSC-specific and metabolic genes. However, only a small fraction of these cysteine protease inhibitor complete full reprogramming, leaving most cells at an intermediate sta

• Table presents the sensitivity analyses described

  2018-11-07

  

  Table 3 presents the sensitivity analyses described previously in the statistical analyses section. The patterns of risk of having poor psychological wellbeing in 2005 and 2007 (compared to 2003 baseline measures) and not trusting were as expected, increasing as the \'caseness’ GHQ-12 cut-off score

14887 records 973/993 page Previous Next First page 上5页 971972973974975 下5页 Last page