• In Fig results of this experiment are shown as

  2020-06-18

  

  In Fig. 1 results of this experiment are shown as the contour plots of endopeptidase activity. Optimal for the enzyme production by this strain concentrations of peptone and inorganic phosphate were found to be 24 and 0.3g/l, respectively. For specific activity, the optima close to those for glutamy

• The reduction of the calcium response to AVP could

  2020-06-17

  

  The reduction of the calcium response to AVP could be also due to a PKA-mediated effect of desensitization of IP3R, as described in rat megakaryocytes [41]. Furthermore, PKA activation inhibits intracellular Ca release in mouse pancreatic acinar cells [42] or in rat cerebellum [43]. The phosphorylat

• Inhibition of DHODH is reflected by an antiproliferative

  2020-06-17

  

  Inhibition of DHODH is reflected by an antiproliferative effect on peripheral blood mononuclear KN-93 hydrochloride synthesis (PBMCs), which can be measured by the inhibitory effect on their phytohemagglutinin (PHA) stimulated growth. The test was performed as described in the reference. Data for f

• The collagen binding membrane proteins discoidin domain rece

  2020-06-17

  

  The collagen-binding membrane proteins, discoidin domain receptors 1 and 2 (DDR1 and DDR2) belong to the family of receptor tyrosine kinase and are expressed in a variety of mammalian cells.7, 8 These transmembrane glycoproteins (∼125 kDa) have been found to be over-expressed or atypically expressed

• RNA sequencing RNA seq is a particularly effective technolog

  2020-06-17

  

  RNA-sequencing (RNA-seq) is a particularly effective technology for gene discovery in a given process, especially in non-model species for which reference genome sequences are not available. Although the major application of RNA-seq analyses is the identification of differentially expressed genes (D

• This study showed that ER redox disturbance associated

  2020-06-17

  

  This study showed that ER-redox disturbance-associated ER stress is linked to cytoplasmic chaperone signaling, including HSP90 stability and its client protein, eNOS. The highly increased PERK and IRE-1α lead to dissociation with the chaperone protein, thereby decreasing HSP90 stability (Fig. 5B). S

• Aminothiazole derivatives have been reported

  2020-06-17

  

  2-Aminothiazole derivatives have been reported to contain antiviral [17], anti-inflammatory [18], and antimicrobial [19] activities. The in vitro anticancer studies showed that different 2-aminothiazole derivatives possess selective and potent inhibitory effect against wide-ranging human cancerous c

• PRRSV is a single stranded

  2020-06-17

  

  PRRSV is a single-stranded, positive-sense enveloped RNA virus in the family Arteriviridae of the order Nidovirales (Meng et al., 1994, 1996). The PRRSV 58 4 is approximately 15 kb in length and contains eleven known open reading frames (ORFs) (Snijder et al., 2013). The 3′ end of the genome encodes

• br Materials and methods br Results br Discussion

  2020-06-17

  

  Materials and methods Results Discussion Oxidative stress is a disturbance in the balance of pro- and antioxidant species, resulting in oxidative damage to membrane proteins, lipids, and DNA. Oxidative stress is a predisposing factor for the progression of metabolic diseases and liver injur

• BCTC On the opposite side sPLA

  2020-06-17

  

  On the opposite side, sPLA2-X has also been implicated in the pathology of cancer [167,168]. Human sPLA2-X induces lipid droplet formation in Ras-driven MDA-MB-231 triple-negative breast cancer BCTC and promotes their survival during nutrient stress. It acts through the products of its enzymatic act

• br Conclusions We can conclude that Arg is important but

  2020-06-17

  

  Conclusions We can conclude that Arg293 is important but not indispensable for MeGlcA recognition by EcXyn30A since the R293A variant still retains activity and preference for MeGlcA-substituted substrates. The substrate specificity of GH30_8 glucuronoxylanases is most probably determined by an o

• Among our patients with anti enolase drusen those with a

  2020-06-17

  

  Among our patients with anti-enolase drusen, those with a relatively short duration from the onset of visual symptoms to the first visit tended to have normal structure of photoreceptors with preserved visual function, despite the presence of drusen-related RPE abnormalities (Cases 1-3 and 8). In co

• br Lymphoplasmacytic lymphoma Waldenstrom macroglobulinemia

  2020-06-17

  

  Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia Lymphoplasmacytic lymphoma (LPL) and its subgroup Waldenstrom macroglobulinemia (WM) are rare and indolent lymphomas that arise from fully differentiated B cells. The only family of GPCRs that has been well studied in LPL/WM is the chemokin

• As CP is a crucial player in centriole duplication

  2020-06-17

  

  As CP110 is a crucial player in centriole duplication, it is intriguing to ask whether centriole duplication would also be affected in the absence of the CP110-stabilizing effects of USP33. Li et al.[4] found that USP33 depletion did not inhibit normal centriole duplication through loss of centriole

• Everolimus treatment showed an increase in

  2020-06-17

  

  Everolimus treatment showed an increase in the number of plaques and a reduction in plaque size, depending on concentration and treatment time (Fig. 1, Fig. 2). Everolimus-pretreated CID 2011756 mg adsorbed less virus with more plaque formation in the initial phase of infection (Fig. 3). The abilit

14926 records 750/996 page Previous Next First page 上5页 746747748749750 下5页 Last page