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br Conclusion br Acknowledgements br
2020-12-17
Conclusion Acknowledgements Introduction In recent years, fast progress has been made toward using the supercritical technology in industrial separation processes. Apart from a green extraction process that replaces organic solvents, applications involving supercritical fluids include super
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br Conflict of interest br Acknowledgements This work was
2020-12-17
Conflict of interest Acknowledgements This work was partially supported by University of Cagliari. Introduction Organophosphorous pesticides (OPs) are wildly used in the world due to high efficiency, broad spectrum and low residue, which in turn results in environmental pollution and adver
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BRCC is the catalytic subunit responsible for the majority o
2020-12-16
BRCC36 is the catalytic subunit responsible for the majority of K63-Ub-specific DUB activity in the cytoplasm and in the nucleus as part of two distinct macromolecular assemblies characterized by the presence of either of the MPN– pseudo DUB proteins KIAA0157 or Abraxas (Cooper et al., 2009, Dong et
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Primases are classified into two
2020-12-16
Primases are classified into two major groups: first, the DnaG primases, found in bacteria and bacteriophages, and second, the archaeoeukaryotic primases. Remarkably, bacterial and archaeoeukaryotic primases have no structural similarity and, presumably, evolved independently (Leipe et al., 1999). T
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In studies directed toward the development of sequence
2020-12-16
In studies directed toward the development of sequence-specific major-groove binding small hcv protease inhibitors [11], we desired a non-intercalating molecular scaffold that could direct attached moieties into the major groove. As an initial step toward this goal, we wished to study the DNA bind
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CAA is a carcinogenic metabolite
2020-12-16
CAA is a carcinogenic metabolite of vinyl chloride, forming several different DNA adducts including the cyclic mma f adducts 3,N4-ethenocytosine (εC), 1,N6-ethenoadenine (εA), N2,3-ethenoguanine (εG), and 1,N2-ethenoguanine (1,N2-εG), with the A and C cyclic adducts the most predominant, and all of
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DGK is not the only DGK isoform that has
2020-12-16
DGKε is not the only DGK isoform that has been associated with p53. It has been shown that DGKζ binds to p53 and modulates its activity in both the cytoplasm and the nucleus [39]. In the cytosol DGKζ promotes the degradation of p53 through the ubiquitin-proteosome system [39], also a likely mechanis
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The first example of a broadly acting
2020-12-16
The first example of a broadly-acting antiviral drug is ribavirin, a nucleoside analogue that was proposed to act directly at the level of the viral polymerase, although an indirect effect via inhibition of the host-cell IMP dehydrogenase and depletion of the GTP pool seems more plausible [9]. Anoth
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A series of monocarboxylated chalcones e
2020-12-16
A series of monocarboxylated chalcones (e.g. compounds 7 and 8, Fig. 2A) was previously identified as good CysLT1 antagonists [20], and none of them exhibited CysLT2 antagonistic activities (Supplementary Table S1). This study was consistent with reported result that CysLT2 5,8,11-Eicosatriynoic Aci
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In S hexyl GSH non treated guinea pigs antigen
2020-12-16
In S-hexyl GSH non-treated guinea pigs, antigen-induced anaphylactic response was suppressed by montelukast, but not by BayCysLT2RA, indicating that this asthmatic response was basically CysLT1-receptor-dependent. On the other hand, the suppressive effect of montelukast was weakened by treatment wit
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Although PGD was initially considered to elicit
2020-12-16
Although PGD was initially considered to elicit its biological actions through a classical PGD receptor (DP1), later findings suggested that several PGD-mediated actions of eosinophils arise via DP2,, which is also known as CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells)
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Helioxanthin derivative 5-4-2 sale Introduction It has been
2020-12-16
Introduction It has been well stablished the role of CRF in somatic pain regulation (Yarushkina et al., 2011, Yarushkina et al., 2016). However, the effects of CRF in pain relief are controversial and it has been described anti- and pronociceptive effects (Ji et al., 1995, Larauche et al., 2009, Ni
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br Conclusions Enzyme can be delivered to the
2020-12-16
Conclusions Enzyme can be delivered to the tumour by using humanised or fully human NU 7026 receptor or even loaded into synthetic nanospheres produced from silica [64] or liposomally entrapped [65]. For any future ADEPT developments, a number of basic points need to be considered. As immunogeni
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br Involvement of p MAPK
2020-12-16
Involvement of p38 MAPK pathway The NF-κB signal transduction cascade is a major stress response signaling pathway for the COX-2 gene expression. In mice and humans, the COX-2 promoter has Torcetrapib mg for many transcription factors, including NF-κB in the 5′ region of the COX-2 gene [11], and
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The Czech Republic is a country with increasing CDI
2020-12-15
The Czech Republic is a country with increasing CDI incidence (1.1 cases per 10,000 patient bed-days in 2008–4.4 cases in 2011–2012 and 6.2 cases per 10,000 patient bed-days in 2012–2013) (Bauer et al., 2011, Davies et al., 2014) and relatively high rates of antibiotic resistant C. difficile strains
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