• 5 of 17000 br Experimental br Results and discussions br Con

  2022-07-16

  

  Experimental Results and discussions Conclusion Notes Introduction The noncanonical DNA structures that is, i-motif [[1], [2], [3], [4], [5], [6], [7], [8], [9]] and G-quadruplex [[10], [11], [12], [13], [14]] have recently been carefully studied using either experimental or computati

• Bromosporine br Ethics approval br Availability of data and

  2022-07-16

  

  Ethics approval Availability of data and materials Consent for publication Competing interests Authors contributions Introduction Glucose supply to tissues is maintained through a complex regulatory network mostly driven by the pancreatic hormones insulin and glucagon which control

• Sildenafil Citrate FGF signals can be transduced to

  2022-07-16

  

  FGF signals can be transduced to the signaling cascades of RAS-MAPK or PI3K-AKT through FRS2 and GRB2, to the pathways of PKC or PKD via PLCγ and DAG, and to Ca2+-releasing cascade via PLCγ and IP3, finally affecting cellular proliferation, cellular survival, and angiogenesis [48]. By increasing syn

• depicts the synthesis of series with a four step sequence

  2022-07-16

  

  depicts the synthesis of series with a four-step sequence. First, the commercially available 4-hydroxybenzaldehyde () was condensed with 2-bromoethanol through Mitsunobu reaction to give the key intermediate (). Next, conventional nucleophilic substitution reaction with the privileged structures (–)

• br Materials and methods br Results br

  2022-07-15

  

  Materials and methods Results Discussion Since early times, herbs and their extracted substances have been used as foods and medicinal resources worldwide (Petrovska, 2012). A Ginger is one of the most important and oldest spices, consisting of the prepared and sun-dried rhizomes of Zingibe

• br Methods br Results We have previously used hex

  2022-07-15

  

  Methods Results We have previously used ß-hex assays in HeLa ptio mg to study the role of lysosomal exocytosis on transition metal clearance and the effects of transition metals on lysosomal exocytosis [26], [29], [40]. ß-hex is a lysosomal enzyme, the delivery of which to the extracellular m

• Thus from this preliminary study a working model of

  2022-07-15

  

  Thus from this preliminary study, a working model of HIV-1 integrase was developed from which a selective inhibitor of the strand-transfer reaction displaying whole-cell activity and negligible cytotoxicity was produced. Compound 9 provides a promising scaffold for further elaboration, and current i

• The analytical approach for the

  2022-07-15

  

  The analytical approach for the simultaneous determination of HA and its metabolites is complex. There are commercial kits that allow the determination of HA through ELISA and of its metabolites through radioimmunoassay (RIA) techniques. However, these immunological-based techniques do not allow sim

• br Acknowledgements This work was supported by NIH

  2022-07-15

  

  Acknowledgements This work was supported by NIH HL111674 (JHF), and the Antoinette E. (“Mimi”) & Herman Boehm Foundation (JK). The authors wish to acknowledge the valuable assistance of the Functional Genomics Core of the University of Colorado, Denver. Introduction The 21-gene recurrence sco

• Since its development the HCV replicon

  2022-07-15

  

  Since its development, the HCV replicon system (Lohmann et al., 1999) has been a critical tool in the HCV antiviral discovery process (Gottwein et al., 2009, Imhof and Simmonds, 2010, Lohmann et al., 1999, Pietschmann et al., 2001, Imhof and Simmonds, 2010, Gottwein et al., 2009). The replicon assay

• It is extremely difficult to

  2022-07-15

  

  It is extremely difficult to predict a plausible conformer of hsGCαβ heterodimer with right orientation of multiple domains. Even though the template identities in case of dimeric domains were not high enough but still we modelled the entire heterodimeric structure of hsGCαβ with a reasonable and ju

• Initial experiments confirmed that RBC

  2022-07-15

  

  Initial experiments confirmed that RBC8 effectively inhibited both RalA and RalB activation in an identical, dose-dependent manner following platelet stimulation with the GPVI-specific ligand, CRP (Fig. 1Ai). Non-specific, upper bands were observed when immunoblotting for activated RalB, with the sp

• br Mutagenesis and Receptor Modeling

  2022-07-15

  

  Mutagenesis and Receptor-Modeling Studies Signal Transduction and Receptor Desensitization Therapeutic Potential of HCA Receptor Ligands Although all members of the HCA receptor family are potentially interesting drug targets, only HCA2 is currently exploited as such. Therefore, this sectio

• In addition to the role of TGR the FXR FGF

  2022-07-15

  

  In addition to the role of TGR5, the FXR-FGF15/19 axis has been implicated in other aspects of glucose metabolism and metabolic disorders. In humans, both obesity and type 2 diabetes mellitus (T2DM) are associated with lower plasma FGF19 levels [67,68]. A derivative of the naturally occurring FXR ag

• It has been found that WHI P a JAK inhibitor

  2022-07-15

  

  It has been found that WHI-P131, a JAK3 inhibitor, induced apoptosis of CD4+ T Alda 1 (Cetkovic-Cvrlje et al., 2012). Also, other JAK3 inhibitors (AG490 and WHI-P154) caused apoptosis in anaplastic large cell lymphoma (Amin et al., 2003). Taking into account the proapoptotic action of JAK inhibitor

15652 records 384/1044 page Previous Next First page 上5页 381382383384385 下5页 Last page