• Studies dealing with the effects of ischemia on EAATs

  2022-07-19

  

  Studies dealing with the effects of ischemia on EAATs have been previously reported, but some discrepancies in literature appear between them probably as a consequence of the different models, species, time of reperfusion after ischemia and age of the animals. Thus, in human, L-NMMA citrate stroke-

• Tail group SAR of the imidazole

  2022-07-19

  

  Tail group SAR of the imidazole derived analogs is shown in . The previous SAR study from the discovery of AMG 837 revealed that a simple un-substituted meta-biphenyl tail group was less favorable in terms of potency. Efforts to introduce polarity to the tail group were not successful. When a methyl

• br Introduction The alternative splicing of

  2022-07-19

  

  Introduction The alternative splicing of pre-mRNA is essential for generating multiple matured mRNAs from a single gene by selectively removing introns. Neural autophagy pathway show many examples of regulated alternative splicing events, which produce structural changes in proteins important fo

• br Genetic rescue of GluR

  2022-07-19

  

  Genetic rescue of GluR-A-dependent spatial working memory Spatial working memory performance in GluR-A−/− mice can be restored by the forebrain-specific Pirarubicin of GluR-A subunits labeled with green-fluorescent protein (GFP) on an otherwise GluR-A knockout background (Schmitt et al., 2005).

• br Discussion In the present study

  2022-07-19

  

  Discussion In the present study, we have demonstrated the effect of a high-fat diet upon wild-type and glut3 pregestational female phenotype and shown that it leads to obesity due to an increase in white adipose tissue contributing to the overall fat mass. Despite this observed obesity along with

• On the other hand with the exception in muscle

  2022-07-19

  

  On the other hand, with the exception in muscle tissue, cGalR2 and cGalR2-L transcripts were also found to be widely distributed among the peripheral tissues at different levels (Fig. 2). The precise functions of cGalR2 and cGalR2-L in these peripheral tissues remain to be established, however, thei

• At the end of experiments rats were injected high dose

  2022-07-19

  

  At the end of experiments rats were injected high dose of sodium pentobarbital (90mg/kg) and the rat’s head was cut and frozen in −20°C for 20min with the injecting tube in situ before section. The location of the tip of the injecting tube was verified and all the tips of the injecting tube were in

• After initial optimization of the

  2022-07-19

  

  After initial optimization of the distances we obtained the structure iG shown schematically in Fig. 1. This is the telomeric fragment of chromosome with the noncanonical structures of i-motif and G-quadruplex placed symmetrically in the middle of the duplex. Obviously, we consider the situation whe

• In the intestine ethanol exposure

  2022-07-19

  

  In the intestine, ethanol exposure can change the composition of gut microbiota and promotes the growth of intestinal gram-negative bacteria, which results in the accumulation of endotoxins such as, LPS. Ethanol also impacts the integrity of the gastrointestinal mucosal barrier, increasing intestina

• br STAR Methods br Introduction Arsenite is a well

  2022-07-18

  

  STAR★Methods Introduction Arsenite is a well-recognized toxic metalloid that commonly presents in the natural environment. Chronic exposure to arsenite can lead to a wide range of adverse health effects to human, including cancers, cardiovascular diseases, diabetes, skin lesion and neurodegene

• To examine the biochemical characteristics of FPPS in Drosop

  2022-07-18

  

  To examine the biochemical characteristics of FPPS in Drosophila, DmFPPS has been functionally expressed in E. coli. The protein displays properties similar to mammalian FPPS, with some notable differences, including the ability to efficiently couple the homologous substrate, homodimethylallyl dipho

• Treatment with histamine had no effect on histamine H

  2022-07-18

  

  Treatment with histamine had no effect on histamine H1 receptor expression in HepG2 Eribulin mesylate (Fig. 1), while knockdown of histamine H1 receptor expression prevented histamine from repressing apo A-I gene expression (Fig. 2). Overexpression of the histamine H1 receptor regulated apo A-I prom

• br STAR Methods br Acknowledgments We

  2022-07-18

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• br Methods br Involvement of HO in rheumatic diseases

  2022-07-18

  

  Methods Involvement of HO-1 in rheumatic diseases Therapeutic strategy targeted HO-1 Based on the researches focusing on the effect of HO-1 in rheumatic diseases, amount of approaches targeting regulation of HO-1 have been arising (See Table 1 for summary). It has been shown that different

• Mathematical models play an important role in understanding

  2022-07-18

  

  Mathematical models play an important role in understanding and predicting the dynamic process of HBV infection. In the 1990s, Nowak et al. proposed a basic model to analyze the effect of antiviral treatment on reducing viral loads (Nowak et al., 1996). Since then, many different mathematical models

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