• We used immunohistochemistry to measure the expression

  2018-10-20

  

  We used immunohistochemistry to measure the expression of RUNX2, SP7, and GFP in the induced 2.3 kb Col1a1-GFP mESCs. RUNX2, SP7, and the 2.3 kb Col1a1-GFP were highly expressed in the induced terbinafine hydrochloride on day 19. RUNX2 and SP7 were colocalized in nuclei, and 2.3 kb Col1a1-GFP was l

• Despite PTC characterization as a tumor suppressor Goodrich

  2018-10-20

  

  Despite PTC characterization as a tumor suppressor (Goodrich et al., 1997), we observed that its deletion in astrocyte-like NSCs increases the stemness of these Homoharringtonine without promoting tumor formation. Our data are consistent with the results observed upon the noninducible deletion of P

• br Acknowledgments br Introduction In

  2018-10-20

  

  Acknowledgments Introduction In the adult hematopoietic system, short-lived mature dna stain are constantly lost and need to be replaced in order to maintain blood homeostasis (Murphy et al., 2005; Weissman and Shizuru, 2008). This essential task is fulfilled by hematopoietic stem cells (HSCs

• Treatment options for xerostomia include administration

  2018-10-20

  

  Treatment options for xerostomia include administration of saliva substitutes or stimulants (Fox, 2004). Saliva substitutes might improve some, but not all, problems associated with SG dysfunction, whereas stimulants are only useful for people with some remaining SG function. Alternative approaches

• The dynamic clonal behavior and conversion of leukemic pheno

  2018-10-20

  

  The dynamic clonal behavior and conversion of leukemic lgk974 that we observed in our mouse model show resemblance with patients presenting with leukemic relapse after treatment. First, if remissions in relapsed patients are treated similarly as the original leukemia, the response is often differen

• A variety of suitable murine xenograft models are currently

  2018-10-20

  

  A variety of suitable murine xenograft models are currently used in hematopoietic research, yet these animals require conditioning prior to experimentation. Given the increasingly restricted access to radiation sources, NBSGW mice are broadly enabling, allowing laboratories without access to radiati

• Our observation that EGF signaling is

  2018-10-20

  

  Our observation that EGF signaling is required for the generation of the equivalent of second-transition progenitors in hPSC differentiation cultures is in line with findings from targeting studies in the mouse that showed that EgfR/ErbB1−/− and ErbB3−/− deficient animals display impaired branching

• br Heteroplasmy mitochondrial segregation and disease In

  2018-10-20

  

  Heteroplasmy, mitochondrial segregation and disease In an individual with a mitochondrial disease, different cells or populations may have differing amounts of the mutant mitochondria, ranging from complete homoplasmy – individuals with all mutant mitochondrial DNA as occurs in Leigh\'s Syndrome

• To determine whether overexpression of

  2018-10-20

  

  To determine whether overexpression of Sca-1 in progenitor cells residing in the bulge and upper isthmus could function as an initiating event, Rosa:Cre mice and control littermates were treated with TPA only. This treatment resulted in very few papillomas that quickly regressed and there was no sig

• In conclusion the MC approach

  2018-10-20

  

  In conclusion, the MC approach described in this study provides a platform to generate a population of human PAX7+ myogenic progenitors from PS vorinostat that can be terminally differentiated into MHC+ myocytes in vitro that is equivalent to iPAX7 cells. However, further development of the method

• br Experimental Procedures br Author Contributions

  2018-10-20

  

  Experimental Procedures Author Contributions Acknowledgments We are deeply thankful to V. Fossati and N. Lamas for helpful critical reading of the manuscript and to J. Goldman for generously providing the O4 antibody. We thank J.-Y. Li for providing access to wild-type mice for deriving mES

• To address this unmet need in

  2018-10-20

  

  To address this unmet need, in this work, we designed MBs targeting IRX4, a ventricular CM-specific transcription factor, generated homogeneous ventricular-like CMs from mESCs without altering their genome, and demonstrated that this method yielded functional ventricular CMs with high specificity an

• br Results and Discussion br Experimental Procedures br

  2018-10-20

  

  Results and Discussion Experimental Procedures Acknowledgments We would like to thank V. Makatounakis and G. Vretzos for technical assistance, as well as I. Stratidaki for her contribution in miRNA sequencing profiling by the Ion Torrent platform (IMBB). We also thank Prof. D. Kardasis and

• br Results and Discussion br Experimental Procedures br

  2018-10-20

  

  Results and Discussion Experimental Procedures Acknowledgments We would like to thank V. Makatounakis and G. Vretzos for technical assistance, as well as I. Stratidaki for her contribution in miRNA sequencing profiling by the Ion Torrent platform (IMBB). We also thank Prof. D. Kardasis and

• The adult mammalian kidney is

  2018-10-20

  

  The adult mammalian kidney is an organ with very low cell cycling during homeostasis but remarkable proliferating capacity after injury. It is still unresolved whether the kidney contains bona fide stem cells. Humphreys et al. (2008) genetically marked cells using Six2, a transcription factor expres

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